They belonged to the same social and professional clubs, knew the same people, traveled together, corresponded and conversed at length, and frequently visited one another's houses.
Note that a full-length TE copy may correspond to two TE fragments, which, when connected together, correspond to the full TE consensus sequence.
The resulting paralogs often have partly overlapping, partly distinct functions that together correspond to the functions of the single ortholog in other vertebrates.
T-tests performed to compare each cluster with the other 3 clusters showed that the first 3 clusters corresponded to our clusters A (6 samples), B (14 samples) and C (12 samples), while the remaining 14 tumors that grouped together corresponded to our D and E tumors (see Figure S6).
In summary, group 1 are up-regulated in growth phase A (rapid growth); group 2 are dominantly up-regulated in phase B (growth slowdown); groups 3 and 4 together correspond to phase C (another rapid growth), with group 3 exclusively up-regulated in phase C, and group 4 up-regulated in both phase B and C (Figure 3).
Hence, a full-length TE copy may correspond to several TE fragments, which, when connected together, correspond to the full TE consensus sequence [ 19].
These severity grades represent very severe (preproliferative) and very mild NPDR respectively and together correspond well with the outcomes used in most previous studies.
For example, the three clades (N5 N7) that together correspond to Clade VII of Jin et al. are consistently shown as trichotomous in our nuclear trees.
In A05, both ends of the chromosome (0 - 5 Mb and 20 - 25 Mb) together corresponded to ~90% of the genetic length.
The length distribution of PacBio reads (Additional file 3: Figure S4) shows that 9.5%% of the reads are longer than 15,000 bp, which taken together correspond to a genome coverage of 3X.
