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This feature inevitably contributes to variance between subjects, so decreasing statistical power.
Biological variability and tissue heterogeneity will significantly contribute to variance between the datasets.
When P values of the Q are above 0.05, the total variance is due to variance within studies and not to variance between studies.
However, if this is true, this external influence simultaneously affected all the HCCs and HCAs and therefore should have had less relation to variance between HCCs and HCAs.
For SBP, 48.8% of the total variance was due to variance between patients, whereas 51.2% of the total variance was seen within patients.
The Der Simonian Laird test of heterogeneity gave a result of p = 0.011, with an estimated 75% total variance due to variance between the studies.
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This difference in expression profiles might have been due to variances between the cells types investigated.
Future testing across services should include cluster analyses to determine whether differences are due to variances between clinicians or organizations, or entirely due to the mode of disclosure.
Another type of calibration may have to be applied to eliminate variance between imaging devices of the same model.
This implicitly removed the effects due to variance differences between phenotypes.
Second, principal component analysis (PCA) was performed to evaluate how different features contributed to the variance between coding and noncoding classes (Fig. 2c).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com