"You have to understand: this functions like a dictatorship," Téllez said.
In order to understand this gene's function, we transformed it into Arabidopsis thaliana; integration (one insertion site) was confirmed following PCR and southern hybridization.
To understand this cell-type specific function of the Lis1 Nde1 complex, we first examined the mitotic orientation of Nde1−/−Lis1+/− progenitors, since both Nde1 and Lis1 are known to play roles in mitotic spindle regulation (26, 28, 29, 35).
What if we could understand this function intuitively, effortlessly?
Systematic DISC1 isoform analysis, whether by generation of exon selective and specific antibodies or through purification and mass spectroscopic identification of individual DISC1 species, is required if we are to understand this fundamental aspect of DISC1 function.
To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA.
To understand this complex barrier, not only the functions of its components, but also the processes of interactions of bacterial and other luminal components with cells and receptors of the host needs to be considered.
Previous attempts to understand this function/mechanism have been more conceptual or theoretical than experimental [23], [27], [54], [56], [57].
To understand the function of this pathway in neural development, we have examined the contributions of multiple components of this pathway in both neuromuscular junction assembly and photoreceptor axon guidance in Drosophila.
Analysis of the trafficking of KIAA0319 is necessary to understand the function of this protein.
The γ1 knockout mice provide a unique resource to understand the function of this protein in myotubes in molecular detail.
