Sentence examples for to underlie altered from inspiring English sources

Thus similar to other human disorders such as Laron dwarfism, type A insulin resistance, and familial hypercholesterolemia in which aberrant down-modulation of growth factor receptors has been shown to play a role in the pathophysiology of these diseases [13] [16], disruption of receptor trafficking also appears to underlie altered cell signaling in SCN/AML.

Altered calcium homeostasis, specifically increased endoplasmic reticulum calcium release, has been linked to a number of sporadic AD risk factors and is thought to underlie altered synaptic transmission and plasticity.

Due to its amenability to genetic manipulations, C. elegans provides a valuable platform for the identification and characterization of genetic factors and polymorphisms that underlie altered responses to heat stroke.

IL-6 was chosen for further investigation to determine the signaling pathway that may underlie altered expression based on its well characterized role in hematopoiesis.

Our data demonstrate greater numbers of VIP-and VP-positive cells and greater FOS expression in response to light and in CBA/J mice, which may underlie altered central processing of photic signals.

Changes in fatty acid synthase, Spot 14, Akt, and DecR1 (2,4-dienoylcoenzyme A reductase) may underlie altered lipid metabolism in tumor cells and contribute to the ability of tumor cells to proliferate or metastasize.

Neurodevelopmental and anatomical alterations of cortical midline structure might underlie altered intrinsic networks in UHR subjects.

Because BTN1 and human CLN3 are homologs, the Btn1p-related biochemical alterations presented in the current work might underlie altered lysosomal function in Batten disease and result in the pathological consequences of this disease.

Regulatory regions, as demarcated by DNAse hypersensitivity sites, have been shown to be enriched for epigenetically variable loci (13), providing support for the conjecture that epigenetic variability may underlie altered expression patterns and thus modulate disease.

An altered RNA binding preference of mutant RBPs could also underlie altered RNA granule formation [ 84].

The WCST data suggest that impairments in global executive function do not underlie altered decision making in CD.