Sentence examples for to this checkpoint from inspiring English sources

Key to this checkpoint is the ATR sensor kinase and Chk1/2 effector kinases; all, if mutated, promote genome instability leading to cancer [ 44].

The concomitant loss of function of p53 affords cells the ability to bypass this checkpoint block and to continue unscheduled proliferation in the face of severe chromosomal instability.

He says that every day about 700 to 800 children are expected to be vaccinated at this checkpoint during the campaign.

For example, mutations in a protein called p53, which normally detects abnormalities in DNA at the G1 checkpoint, can enable cancer-causing mutations to bypass this checkpoint and allow the cell to escape apoptosis.

All these key molecules can be targets of the biosurfactants used, but it is important to notice that at this checkpoint the cell can also stop proliferating due to entrance in a latency phase, the so-called G0 phase.

The high prevalence of TP53 mutations in hereditary [20] and sporadic [38] ovarian carcinomas suggests that this gene is a frequent mutational target of the selective pressure for aneuploid cells to overcome this checkpoint.

Because of the varied negative signals resulting from interactions between PD-1/PD-L1/PD-L2 and PD-L1/CD80, there are opportunities to target this checkpoint pathway from two directions: PD-1 blockade inhibits negative signaling induced by PD-L1 and PD-L2 ligation, whereas PD-L1 blockade inhibits negative signaling via PD-1 and CD80.

As we came to this crossroads, Checkpoint 16, the Afghans took up positions in a field to the north and American soldiers in another to the south.

It is likely that inherited genetic factors may affect the biology of the host or their cancer cells to determine the likelihood of immune responsiveness; to this first checkpoint, the genetics of cancer cells may add its own predisposition to being susceptible to immune attack.

To be clear, this app alerts you to the checkpoint.

"How can I give an order to anybody -- 'Take this checkpoint away,' or 'Don't make a closure on Nablus' -- if I know that there is infrastructure in Nablus that is ready to send someone on their way" to bomb an Israeli city?