Despite this absence of empirical evidence, interviewees still support this rationale, because it is stipulated in 45-CFR-46 45-CFR-46 45-CFR-46tify their existence, efforts, and expense.
There are at least three important factors that support this rationale.
DFT calculations support this rationale as the additional coordination makes the gold carbene more stable.
The habit is to prescribe more last-line agents (typically carbapenems) in more pronounced disease expression, albeit that there is little rationale to support this practice.
Our ethics consultants were encouraged to conduct HCEC following the ethics facilitation approach as proposed by Aulisio et al. Part of the rationale to support this approach to conducting HCEC in the U.S., according to Aulisio et al. [ 20], are that the U.S. is a pluralistic society, and the main societal value is individual autonomy.
However, it was one of about 25 pre-specified subgroup analyses (rather than one of few), it was not consistent across different definitions of high risk (such as presence versus absence of multiple organ failure, mechanical ventilation, or vasopressor support) [ 11], there is no other independent evidence to support this subgroup effect, and the biological rationale for it is unclear.
Its dosimetric rationale and evidence to support this approach are detailed in Additional file 1.
In other words, a YES response would require systematic review authors to report perceived risk of publication bias, with a strong argument/rationale to support this statement.
They did not measure circulating endotoxin levels or inflammation markers (e.g. sCD14 or CRP) to support the rationale for this study, although they do cite a publication by one of the co-authors (Ref 3) that supports this hypothesis.
