Exact(1)
Since different parametric methods differ in their characteristics, real design process needs flexible choice among them to adapt to subsequent optimization procedure.
Similar(59)
The compromise programming method is first applied to describe the statically loaded multi-stiffness topology optimization, and the dynamic formulation is used to establish the subsequent optimization problem mainly concerned with free vibration.
Consistent with our previously described multivalent design approach to this target, subsequent optimization of the linker and secondary binding group regions of the series afforded compound 18 (TD-8954), a potent and selective 5-HT4 receptor agonist in vitro with demonstrated prokinetic activity in multiple species.
However, we find that first finding the optimal rotation parameters and keeping it fixed, as described in [33] leads to errors in subsequent optimization steps when the rotation estimate is flawed.
Then, the service time is used to define appropriate throughput capacity constraints to be incorporated into subsequent optimization runs.
Herein we describe how NMR enables the characterization of nanosystems at different stages of their formation and modification (raw materials, bare or functionalized nanosystems), even making it possible to study in vivo nanoparticle interactions, thereby importantly contributing to nanoparticle design and subsequent optimization.
Based on case studies we demonstrate that the method decreases the number of decision variables for subsequent optimization dramatically to app. 30 to 40percentt.
This would require sequencing of a metagenomic library to identify target genes and subsequent optimization of the codons and signal sequences of these to suit the expression host.
Subsequent optimization led to a series of potent, selective antagonists.
Then, the dataset is split into multiple segments to be used in the subsequent optimization process.
Subsequent optimization led to the identification of CTN06.
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