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The aim of this study was to study targeted surfactin structural analogues biosynthesis in response to culture conditions in view of the design and production of tailor-made lipopeptides.
To study targeted preamplification, we used 96 individually optimized qPCR assays (Supplementary Table 1).
The remarkable effectiveness of these drugs in molecularly selected populations has led to a surge in lung cancer trials to study targeted therapies in other molecularly selected populations.
This work used whole exome capture and massively parallel DNA sequencing to study targeted candidate mutations in selected genes, as well as performing a "hypothesis-free" analysis where we aimed to identify potential driver mutations by identifying variants with increased proportion of mutant alleles.
Moreover, the age-group structure of the model, by dividing the population into seven groups of the very young, preschool children, younger and older schoolchildren, young adults, adults, and the elderly, allows us to study targeted public health policies (e.g., immunization) aimed at different age groups.
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Measurements of a local tissue RAS component (such as AT1Rs) in clinical or experimental CKD studies may be more predictive of the degree of renal injury compared to studies targeting the circulating RAS components.
However, this seems an unlikely explanation for the present findings, because restricting the meta-analysis to studies targeting daytime workers only did not affect the association.
In addition to studies targeting potential biological mechanisms, future collaborative efforts are needed to study whether migraine aura specifics or the course of migraine influences risk of subsequent ischaemic and haemorrhagic vascular events.
Similar to studies targeting hyperglycemia, the magnitude of the benefit associated with case management was greater when a treatment algorithm was used (additional reduction of systolic BP of 9.4 mmHg).
To study target selectivity of THOC5, we recently performed transcriptome analysis of immediate-early genes in the presence and absence of THOC5.
Here, we used target-enrichment strategy coupled with next generation sequencing technique to study target regions which were found to be associated with milk production traits in dairy cattle in our previous GWAS.
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CEO of Professional Science Editing for Scientists @ prosciediting.com