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Three different methods cut-off, time-of-flight, and Pulsed Field Gradient Nuclear Magnetic Resonance were used to study downstream flow of fine granular material through the fixed bed reactor.
HEK293 cells also appear to have an almost full complement of G protein isoforms for each subunit, making these cells an attractive environment to express any number of GPCRs to study downstream G protein-mediated signaling.
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Measurements of SEP events recorded by the Solar TErrestrial RElations Observatory (STEREO) supplemented by Mars Express measurements can potentially allow the predictions of SOLPENCO to be further studied downstream using a large statistical sample.
These RASSLs will be a powerful tool to study the downstream effects of constitutive and ligand-mediated Gs-signaling in vivo.
RNAi was used to study the downstream mediators of miR-17-92 miR-17-92 miR-17-92
Further, RNA interference and kinase inhibitors were also used to study the downstream signals.
Finally, this investigation is limited by the inability to study the downstream targets of the differentially expressed miRNAs in vivo.
Paraffin-embedded tissue slices were processed to generate 5 μm tissue slides, which were used for H&E staining and to study the downstream effects of sTRAIL.
We could not assess activation of the ras signalling pathway, but chose to study the downstream effects of the FTI, measured as change in apoptosis and proliferation.
Our findings demonstrating effective and selective degradation of BRD4 with a PROTAC approach open up unprecedented opportunities to study the downstream physiological and pathological consequences of BRD4 modulation.
Because of the importance of ECM cues in signaling pathways, careful control of the ECM is extremely important when studying downstream signaling events or cellular response to soluble factors such as pharmaceuticals.
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