Exact(1)
The final structure is presented by MODELLER (Sali and Blundell 1993) using a program that creates a probability density function using geometric criteria that satisfies spatial restraints within the query sequence in comparison to solved structures.
Similar(7)
From mPGES1* purification to solved structure took ∼8 months.
Concerted structural genomics efforts have been carried out across different research groups to solve structures for strategically chosen members from DUF families and to bridge the gap between known sequences and their function [ 2].
Here we used cryo-electron microscopy to solve structures of GATOR1 and GATOR1 Rag GTPases complexes.
"We're building tools that will allow us to solve structures at a historically unprecedented rate," said Dr. Nathaniel E. David, director of business development at Syrrx, a new structural genomics company based here in San Diego.
In particular, the new algorithm is able to solve structures, consistently, for which RNAinverse is unable to find solutions.
They are very powerful tools to solve structures, for instance, the Cryo-EM was applied to determine TrpV1 structures (Cao et al., 2013; Liao et al., 2013).
Given the inevitable errors in measuring the intensities, and the mathematical difficulties of reconstructing atomic positions from the interatomic vectors, this technique is rarely used to solve structures, except for the simplest crystals.
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