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When a patient fails to respond as expected to appropriate therapy, or announces at the first consultation that he or she has already tried everything and nothing will work, it is important to identify the reason or reasons that treatment has failed.
However, when dealing with tailored therapies, the failure of an entire series of patients to respond as expected (i.e., to not respond at all or respond to a higher dose or in a delayed manner) is an unusual and exceptional event and, as such, could prove extremely valuable in rejecting or modifying the hypothesis generated in the previous phase.
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Recently, researchers in Finland made the discovery that some people's bodies do not respond as expected to weight training, others don't respond to endurance exercise and, in some lamentable cases, some don't respond to either.
Here, we show that comparing the prevalence of fire-sensitive to fire-adapted taxa in the pollen record can help distinguish periods when vegetation does not respond as expected to climate change.
As shown in Figure 2, the NAD(P H and FP components respond as expected to KCN and FCCP treatment.
We show that these constructs 1) respond as expected to endogenous zebrafish hormones and cofactors, 2) facilitate efficient receptor and cofactor purification, 3) respond robustly to NR hormones and drugs and 4) yield readily quantifiable signals.
For instance, approximately 30% of patients with NSCLC with activating EGFR mutations do not respond as expected to TKIs against EGFR [ 1, 14].
Such an approach was often constrained by a lack of understanding of the complex behaviour of local health systems, which often do not respond as expected to external interventions and policies.
"The co-pilot stated the airplane did not respond as expected and continued to descend".
And even when they are, a stock may not respond as expected.
That strategy, however, can punish profits, particularly if consumers do not respond as expected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com