Simulations with the mathematical model demonstrate the model's behaviour to be consistent with important characteristics of the development of tolerance to repeatedly administered drugs: the gradual decrease in drug effect when tolerance develops, the high sensitivity to small changes in drug dose, the rebound phenomenon and the large reactions following withdrawal in dependence.
The model assumes the development of tolerance to a repeatedly administered drug to be the result of a regulated adaptive process.
Among other things, Dr. Grodstein is expanding the study with a telephone test that researchers will repeatedly administer to participants over time.
The violence has badly affected vaccination efforts, which involve tens of thousands of health workers who repeatedly administer cheap oral vaccines to children under 5. Nine polio workers were killed in a string of attacks across the country in December.
Yesterday, before Justice Bonnie Wittner of State Supreme Court in Manhattan, she pleaded guilty to recklessly and repeatedly administering sedatives that caused his death.
Third, tests were repeatedly administered to three professors in the industry, and to two medical specialists and five patients; a pilot run of the questionnaire was administered to 37 patients.
Third, tests were repeatedly administered to three academic professors in the industry, and to two medical specialists and five nurses with experience of job rotation; a pilot run of the questionnaire was administered to 38 nurses.
In addition, when i.v. doses were repeatedly administered to dogs, myocarditis and nephritis were observed.
Additional bias may result if the questions are not reliable, that is the questionnaire will not always result in the same response when repeatedly administered to the same respondents.
However, because SPRC contains sulfur amino acids and polar molecules, it is dissolved, absorbed and eliminated very quickly; therefore, it must be repeatedly administered to maintain an effective concentration.
