While it is undeniably true that members of these groups "live in daily fear of reprisals" and are consequently "reluctant to seek help," the social attitudes and laws that serve to marginalize them do more than discourage them from accessing care; they ensure that available clinical services remain unresponsive to their needs.
Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs.
We refer to the latter state as the "state of no return", because it is marked by repressive epigenetic modifications, which remain unresponsive to RA [9].
Those J-Lat cells that remain unresponsive to the combined treatment are probably regulated by repressive epigenetic marks that cannot be reversed solely by inducing NF-κB and inhibiting HDAC activity.
As expected, p16ink4a confers a 32% increase in the G1-phase cells and a 25% reduction in S-phase cells in Lmna+/+-Cont cells, while the Lmna+/+-Gank cells remain unresponsive to p16ink4a overexpression (Figure 3C).
In immunogenicity studies, some infants (1%–3%) remain unresponsive to conjugate vaccines (5 ).
However, patients in the favourable subset constitute only a minority of CUP cases and most patients remain unresponsive to any treatment modalities and have a worse prognosis.
Furthermore, the fact that many breast tumors remain unresponsive to existing drugs warrants further searches for alternative targets, possibly compensatory genes in the same pathway.
Alternatively, in systems where females have full control over mating probability and mating partners are chosen randomly, theoretical work predicts that mating rates should remain unresponsive to variation in population density [ 11].
In the in vitro system, it may be ascribed to low levels of CXCR4-expression on DCs used, however, we show that DCs expressing a comparable level of the two co-receptors remain unresponsive to X4 viruses.
