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This association has been hypothesized to reflect alterations in neural circuits supporting bottom-up threat processing and top-down executive control.
Because of its unique nature, the sperm epigenome and the marks which seem to reflect alterations or perturbations in spermatogenesis are thought to provide a predictive insight.
The decreased production of kynurenine from tryptophan may result from the compromise of hepatic function in the fetus, whereas the increased production of kynurenic acid and quinolinic acid in the brain is likely to reflect alterations of metabolism of tryptophan and kynurenine to these neuroactive products by glial cells in the fetal brain.
In this light, the drop in anxiety in the active group is likely to reflect alterations in this anticipatory processing.
In such situations, a Markov model can be used to reflect alterations in health states during the period of CEA.
On the other hand, if ΔSO2 and Δ[Lac] result from mixing of SVC with coronary venous blood, either in part or in whole, then it is possible for these gradients to reflect alterations in myocardial oxidative metabolism [ 4, 6].
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This is caused in part by our current limitation of in-depth knowledge of this process in general and a respective lack of adequate tools and prime candidates suited to reliably reflect alterations of gastrointestinal Se uptake.
It is intriguing to speculate that this may reflect alterations to cell physiology in roots that affect changes in permeability to water and nutrients.
The three variants that did not conform to the hierarchy could potentially reflect alterations to the mRNA sequence context near the mutation rather than the effect of a synonymous substitution per se.
For a matrix protein to be involved in regulation of gene expression, and be involved in the rearrangements seen in nuclei as new programs of gene expression are induced[53], it would need to be part of the nuclear matrix, be able to pinion chromosomes to the matrix, and reflect alterations in gene expression.
These challenges have served to motivate the application of novel analytical approaches for retrospective studies of DNA methylation that aim to distinguish epigenetic marks that are consequential or reflect alterations to the methylome driven by the tumor itself, from those that are causal or mediate tumor growth and development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com