In contrast, GPI cleavage failed to reduce the expression of circumsporozoite protein (CSP), the main protein expressed at the surface of Plasmodium sporozoites.
We used RNAi to reduce the expression of the five napin genes and deplete the seeds of this SSP.
Our previous experience with Raloxifene has documented its ability to reduce the expression of NF-κB making a plausible role for SERMs in management of IBD.
Small interfering RNAs (siRNA) are double-stranded RNAs of 9 29 nucleotides designed to reduce the expression of homologous genes by a process known as RNA interference (RNAi).
RNA interference (RNAi) is an essential method in molecular biology to reduce the expression of target genes and thereby determine their function.
Infusion of the CLA treatment reduced the mRNA expression of acetyl-coenzyme A carboxylase and fatty acid synthetase by 46 and 57%, respectively, and tended to reduce the expression of SCD1 and lipoprotein lipase.
The use of siRNA to reduce the expression of a target gene can induce the expression of one or more tissue-inductive factors, direct the differentiation of stem or progenitor cells, or remove a factor that inhibits regeneration.
In addition, EPO has been shown to reduce the expression of proinflammatory mediators, TNF-alpha and IL-2, in IR renal injury and reverse the effect of endotoxin on the antioxidant, renal superoxide dismutase (SOD).
Similarly, drugs with activity in this domain, such as the HMG-CoA reductase inhibitors, suppress the levels of soluble P-selectin and would consequently be expected to reduce the expression of tissue factor [71 74].
To our knowledge, this is the first study in which a terminator-based strategy has been successfully developed to reduce the expression of argF and enhance l-ornithine production.
