In contrast, GPI cleavage failed to reduce the expression of circumsporozoite protein (CSP), the main protein expressed at the surface of Plasmodium sporozoites.
We used RNAi to reduce the expression of the five napin genes and deplete the seeds of this SSP.
Our previous experience with Raloxifene has documented its ability to reduce the expression of NF-κB making a plausible role for SERMs in management of IBD.
Small interfering RNAs (siRNA) are double-stranded RNAs of 9 29 nucleotides designed to reduce the expression of homologous genes by a process known as RNA interference (RNAi).
RNA interference (RNAi) is an essential method in molecular biology to reduce the expression of target genes and thereby determine their function.
To our knowledge, this is the first study in which a terminator-based strategy has been successfully developed to reduce the expression of argF and enhance l-ornithine production.
In addition, EPO has been shown to reduce the expression of proinflammatory mediators, TNF-alpha and IL-2, in IR renal injury and reverse the effect of endotoxin on the antioxidant, renal superoxide dismutase (SOD).
Similarly, drugs with activity in this domain, such as the HMG-CoA reductase inhibitors, suppress the levels of soluble P-selectin and would consequently be expected to reduce the expression of tissue factor [71 74].
We next introduced TrpC3-shRNA into these cells to reduce the expression of TrpC3.
Accordingly, inhibition of the PI3K/AKT pathway with LY 294002 has been shown to reduce the expression of FASN [39].
Interestingly, STAT1, through which IL-21 also signals, has been shown to reduce the expression of Bcl-2 [38].
