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This has particular relevance as the CAT provides an additional tool to assess the ability of novel interventions to reduce exacerbation severity and make comparisons across studies easier.
Early identification and prompt treatment of exacerbations has shown to reduce exacerbation recovery time, while improving health related quality of life and reducing the risk of hospital admission[ 10].
24 Though health education did not seem to have obvious and directly positive effects on the rate of decline in FEV1 (data not shown), previous trials have shown that it can help to reduce exacerbation of and mortality from COPD and improve quality of life.
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These mechanisms support a role for vitamin D as secondary prevention to reduce exacerbations and inflammation in asthma.
Ciprofloxacin DPI is in development as a long-term, intermittent therapy to reduce exacerbations in patients with non-cystic fibrosis (CF) bronchiectasis and evidence of respiratory pathogens.
Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) has potential to be the first long-term intermittent therapy approved to reduce exacerbations in NCFB patients.
Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on therapy to standard of care for patients with severe eosinophilic asthma, has been shown in previous studies to reduce exacerbations and dependency on oral corticosteroids compared with placebo.
Long-acting bronchodilators are regularly used for the treatment of asthma patients and in clinical studies the anti-cholinergic tiotropium has recently been shown to reduce exacerbations in patients with asthma.
51, 62– 68, 69, 69 Medications shown to reduce exacerbations in COPD are described in Table 3.
2, 4 Furthermore, optimal management is proven to reduce exacerbations and enhance quality of life.
62– 66 However, data comparing LABA/ICS to tiotropium are limited 67 although both have been shown to reduce exacerbations individually.
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