A scheme of the experiments and the hypotheses that they were designed to address are shown in Table 2. Uterotrophic assays were conducted using IF at different concentrations selected to provide a concentration-dependent response (experiments 1 and 2).
We then calculated plasma nitrate concentrations by subtracting plasma nitrite from the sum of nitrite and nitrate to provide nitrate concentrations.
The simulated AUC24/MICs were designed to provide peak concentrations (Cmaxs) close to the MIC, between the MIC and the mutant prevention concentration (MPC), i.e., within the mutant selection window (MSW), and above the MPC.
Diets were alfalfa-based total mixed rations that were formulated to provide similar concentrations of NEL and CP while differing in rumen degradability of concentrate carbohydrates.
Diets were formulated to provide 4 concentrations of dietary RDP [6.8, 8.2, 9.6, and 11.0% of dry matter (DM ] while rumen-undegraded protein remained constant (5.8% of DM).
The rations were formulated to meet the nutrient requirements of feedlot calves (NRC 2001) and to provide equal concentrations of protein and energy in both of the diets across the treatments.
For instance, polymeric nanoparticles are encapsulated with Tacrine for intravenous drug delivery system to provide high concentrations of Tacrine in the brain and reduce the total dose required for the therapy [52].
To overcome this instability, a flavin oxidoreductase gene (frp) from Vibrio harveyi was co-expressed to provide sufficient concentrations of the FMNH2 co-factor required for the bioluminescent reaction.
The simulated AUC24/MIC ratios were designed to provide ciprofloxacin concentrations within the MSW over most of the dosing interval (bolus administration) or over the entire dosing interval (continuous infusion).
