Sentence examples for to prion from inspiring English sources
noun
A self-propagating misfolded conformer of a protein that is responsible for a number of diseases that affect the brain and other neural tissue.
Occasionally, genetic mutations lead to prion diseases that run in families.
Some people may have a genetic susceptibility to prion diseases, whereas others may have a natural resistance.
Soon afterwards, so-called knockout mouse studies (which abolished the prion gene in mice making them resistant to prion infection) added further evidence.
From volcanology to climate, bird flu to prion disease, we need to be sure that the best available knowledge is just that – available.
Regular mice infected with prions soon succumbed to prion disease.
Because TGV has been already approved as a medicine, its extension to prion diseases is straightforward.
Three capturable aptamers were designed based on the PrP aptamer, which binds to prion protein.
Adding single-stranded RNA, conversely, stimulated the transformation of normal PrP to prion PrP.
The molecular mechanisms contributing to prion conversion and the impact of PrPSc accumulation on cellular biology are not fully understood.
Our study sheds light on the role of the helical structure of amyloid fibrils, which is related to prion infectivity, in determining their mechanical deformation mechanisms and properties.
These results could open the way to raising PrP-like mAbs, which might serve as surrogate antigens in a new active immunotherapeutic approach to prion diseases.
