Sentence examples for to predict binding for from inspiring English sources
A weighted, thresholded linear model class was used to combine the motif scanning feature with zero, one or two additional features to predict binding for the five TFs.
More recent approaches have used cell type-specific mammalian epigenetic or transcriptional data to predict binding for a single TF in mammals (Nykter et al., 2009; Wang et al., 2009).
One study combined pocket prediction with evolutionary conservation in order to predict binding sites for an arbitrary small molecule (Huang and Schroeder, 2006).
We also point out that in practice it is not appropriate to use the HS data alone to predict binding sites for a TF as the predictions would not be specific to the TF of interest.
The present work is focused on the development of new machine learning models to predict binding affinity for CDK.
Alchemical free energy calculations were performed with the software FESetup and Sire/OpenMM to predict binding affinities for three congeneric series subsets.
Regions that display differentiation-dependent changes in hypersensitivity were used to predict binding sites for proteins involved in adipogenesis.
Thus, using more diverse peptides might be required to predict binding energy for more diverse sequences.
To predict binding specificities for a given ERBB2IP-1 multi-mutant sequence and some ligand position, we had to convert model scores to PWM probabilities.
It is reasonable to assume that a method should perform well on the single-mutant data before attempting to predict binding preferences for multi-mutant domains.
Because of this extraordinarily high degree of variation in the ligand binding site, as well as relatively modest binding affinity (Kd of tens-to-hundreds µM), it is extremely difficult to predict binding partners for the large BRD family with knowledge of only three available structures of BRD and acetyl-lysine-peptide complexes [6].
