Given that they cannot change their environment, such firms seek to position themselves optimally within it.
This dynamics allows mobility in the template strand, which facilitates the wobble pairing between an incoming dTTP and dG*, because the N-clasp flexibility permits the template base to position itself optimally for wobble pair geometry.
Three categories of 'hands on' help identified were, 1) 'minimal assistance' when helpers touched babies to position them optimally or closer to the breast; 2) 'moderate assistance' where helpers touched mothers' breasts or babies to help babies attach to their mothers' breast and 3) 'full assistance' help to both position and attach babies to mothers' breasts.
Indeed, when we superimpose PDZ domain binding affinities with gene ontologies, network topology data and the domain position within a PDZ superfamily protein, functional overlap is minimized and PDZ domains position optimally in the binding space.
When NADPH binds the enzyme containing bound pOHB, the flavin is triggered to move to the OUT conformation (state 3) where the N5 of the isoalloxazine is positioned optimally to receive a hydride from NADPH; this transition only occurs when substrate is bound.
A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.
Similarly, we recently proposed that the C-terminal redox center of DmTR containing a C-terminal Ser-Cys1-Cys2-Ser disulfide bond is positioned optimally to be activated for thiol disulfide exchange because of polarization of the disulfide bond by His464′ (equivalent to His509′), as explained in the legend of Figure 3A.
Jupiter's brightness and size, however, confused the adaptive optics (AO) system, forcing the astronomers to miss some good shots of the planet as the guide star was being positioned optimally relative to Jupiter.
Given a reflecting geometry, the obtained lower bounds allow the radar operator to anticipate blind spots, place confidence levels on the localization results, and permit sensor positioning to optimally aid in exploiting multipath for target localization.
Based on sequence analysis suggesting that Beclin 1 residues 80 104 that precede the BH3 domain are helical when bound to a suitable partner (Mei et al., 2014), a model for this region was built by 'in silico' mutagenesis of the MK2-bound auto-inhibitory peptide to correspond to Beclin 1 residues 80 95, such that S90 was positioned optimally for phosphorylation.
