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A hydrophilic spacer consisting of a polyethylene glycol, the 8-amino-3,6-dioxaoctanoic acid (abbreviated as O2Oc), was selected to permit accessibility and compatibility with the enzymatic assay.
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Thus BET family members have an important general role in permitting accessibility of transcription factors to the Ifnb promoter.
The N, N-dimethyl, N, N-diethyl and pyrrolidinyl substrates appear to have the correct balance of nitrogen basicity and steric accessibility to permit palladation.
For that reason, the resolution urges "congregations to advocate for the necessary changes in local, state, and federal law to permit the medicinal use of marijuana and ensure its accessibility for that purpose".
Methylome data, coupled to the analysis of restriction-modification systems, allowed us to substantially increase the genetic accessibility of B. longum subsp. longum NCIMB 8809 to a level that was shown to permit site-directed mutagenesis.
Histone H3 acetylation and Lys-4 trimethylation (H3K4me3) permit greater accessibility of DNA to transcription factors, whereas Lys-27 trimethylation (H3K27me3) or Lys-9 dimethylation (H3K9me2) are associated with gene repression.
The degree of nanoscale deconstruction displayed in samples treated within the SG and HS reactors can be explained by dramatic increases in the surface area of cellulose microfibrils permitting increased accessibility by hydrolytic enzymes.
For example, permit applications for developed land uses are generally required to document accessibility of utilities and suitable road access.
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These structural changes most likely permitted increased cellulose accessibility to enzymes, enhancing saccharification.
This in turn leads to greater accessibility of the DNA in this region, which permits the binding of the transcription factor nuclear factor 1 (NF1), but it remained unclear which molecular processes are driven by NFI [ 4].
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