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Autologous cartilage regeneration remains the mainstay for repairing articular cartilage defects but more studies are required to optimize the efficacy of regeneration.
Examples of regenerative rehabilitation include the incorporation of physical activity to promote engraftment of stem cells into muscle tissue and the in vitro use of mechanical stimuli on cultured cells or tissues, as a means to optimize the efficacy of cell therapeutics and tissue engineering technologies.
In the attempt to optimize the efficacy of chemotherapy in advanced non-small cell lung cancer (NSCLC) several strategies need to be investigated including the use of non-platinum combinations and the sequential use of different agents.
In order to optimize the efficacy of the technology, the aim of this study was to design and validate a model system for steam surface pasteurization, assessing different inoculation methods and realistic microbial levels.
Moreover, response surface method, based on central composite design (CCD) experimental plan, was utilized to analyze, to model and to optimize the efficacy of membranes in removal of Pb2+ from water.
Mean pH value observed in the water samples varied from 6.8 to 7.4 as shown in Tables 2 and 3. Most water treatment processes, particularly clarification and disinfection, require pH control to optimize the efficacy of the process.
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These characteristics are critical to the establishment of a relevant model in which to conduct preclinical studies to optimize the efficacy and safety of cell-based therapeutic approaches to the treatment of PD.
Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens.
In order to optimize the efficacy and safety of VLP-based vaccines, adjuvants are included in most vaccine formulations.
Accordingly, research efforts are ongoing to optimize the efficacy and safety profiles of stimulation protocols.
Due to the relative cost and technical demand associated with transplantation experiments in non-human primates, studies aimed at defining molecular mechanisms with potential to help optimize the efficacy of donor spermatogonia are being applied primarily in rodent models [41].
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