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Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens.
In order to optimize the efficacy and safety of VLP-based vaccines, adjuvants are included in most vaccine formulations.
Autologous cartilage regeneration remains the mainstay for repairing articular cartilage defects but more studies are required to optimize the efficacy of regeneration.
Examples of regenerative rehabilitation include the incorporation of physical activity to promote engraftment of stem cells into muscle tissue and the in vitro use of mechanical stimuli on cultured cells or tissues, as a means to optimize the efficacy of cell therapeutics and tissue engineering technologies.
These characteristics are critical to the establishment of a relevant model in which to conduct preclinical studies to optimize the efficacy and safety of cell-based therapeutic approaches to the treatment of PD.
In the attempt to optimize the efficacy of chemotherapy in advanced non-small cell lung cancer (NSCLC) several strategies need to be investigated including the use of non-platinum combinations and the sequential use of different agents.
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At Mission Health, she is focused on the use of pharmacogenomics in routine health care to help optimize the efficacy and safety of drug therapy.
Due to the relative cost and technical demand associated with transplantation experiments in non-human primates, studies aimed at defining molecular mechanisms with potential to help optimize the efficacy of donor spermatogonia are being applied primarily in rodent models [41].
Metronomic chemotherapy regimens were developed to optimize the antitumor efficacy of agents that target the tumor vasculature instead of tumor cells, and to reduce toxicity of antineoplastic drugs [1].
In order to optimize the chemotherapeutic efficacy of doxorubicin (DOX) and improve the photodynamic therapeutic effectiveness of rose bengal (RB), a mesoporous silica nanoparticle system was designed as the carrier of RB and DOX for chemo-photodynamic combination therapy.
The active dose could be correlated with the expression level of the targeted molecule, and its measurement could be a guide to optimize the clinical efficacy.
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