Sentence examples for to optimize potency from inspiring English sources

The efforts were undertaken to optimize potency and selectivity of this class of compounds.

X-ray structure driven template modification and exchange of the benzamidine to optimize potency and pharmacokinetic properties gave selective, potent and orally bioavailable 4- 3-aminomethyl phenyl)piperidinyl-1-amides.

A structural selectivity rationale was used to optimize potency and biopharmaceutical properties and led to the development of a transcriptional inhibitor, 3,4-dimethyl-5-[2- 4-piperazin-1-yl-phenylamino -pyrimidin-4-yl]-3H-thiazol-2-one, with anticancer activity in animal models.

These findings should facilitate efforts to further probe the physiologic functions of these molecular chaperones and support efforts to optimize potency and efficacy in developing HSP70 and DnaK modulators for therapeutic use.

Our findings thereby provide a new chemical scaffold and target platform for both HSP70 and DnaK; these will be important tools with which to interrogate chaperone function and to aid ongoing efforts to optimize potency and efficacy in developing modulators of these chaperones for therapeutic use.

To optimize the potency of the ECT, a balance between adequate anesthesia and optimal duration of induced seizure is crucial.

Here, we applied multiple approaches to optimize the potency and selectivity of our reported alloxazine scaffold.

A structure activity relationship was developed in order to optimize their potency and selectivity.

Topliss operational method was used to optimize the potency of molecules.

Further synthetic modification was undertaken to optimize the potency of amide compounds.

Substituents on the inhibitor scaffold were varied to optimize target potency, antibacterial activity and in vivo pharmacokinetic stability.