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Early phase clinical trials frequently combine targeted agents to optimize benefit.
In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly from the immature CNS [49] [53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated from precursor cells in vitro in order to optimize benefit.
The majority of GPs considered that, to optimize benefit for patients, such courses should be integrated in a comprehensive therapeutic plan.
Taken together, these findings provide experimental evidence in humans to support aggressive normalization of plasma glucose using insulin in patients with T1DM who experience repeated bouts of ischemia, in order to optimize benefit from insulin-induced protection and endogenous protection by ischemic preconditioning.
In addition, because of its psychoactive side effects, difficulty in dose titration to optimize benefit, minimize side effects like dizziness, dysphoria, depression, hallucinations, alteration in psychomotor function and paranoia, time to response and long-term effects when taken orally limits the use of this agent for all cancer patients with symptoms of cancer anorexia [ 41].
Taken together, these data provide human experimental evidence for aggressive normalization of plasma glucose in patients with T1DM who experience repeated bouts of ischemia, such as angina pectoris or transient ischemic attacks, in order to optimize benefit from endogenous protection by ischemic preconditioning.
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Thus, our study suggests that a better adherence to antihypertensive agents is related to a risk reduction of ESRD and this adherence needs to be improved to optimize benefits.
Strategies for better educating patients about these issures merit attention, and research to identify effective approaches to educate patients and their parents to the potential that treatment side effects may arise which may undermine wellbeing so that early ameliorative action can be taken to optimize benefits and minimize harms.
Further, amphibian conservation efforts should account for potential Allee effects in order to optimize benefits and avoid underestimating critical population thresholds, particularly in species exhibiting rapid population declines.
Trained health care provider teams should focus on how to adequately select, train, manage, and motivate patients to optimize benefits from CGM.
Gruman et al. identified a range of behaviours that individual consumers might embrace to optimize benefits they obtain from the health system [ 81].
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