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At the Middlesex Hospital in London, the surgeon who helped develop radium for uterine cancer did so on inoperable patients, but it worked well enough that he came to offer "operable" patients a choice of therapy.
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The aims are to reduce tumour burden thereby making inoperable tumours operable and to offer breast-conserving surgery to those patients where a sufficient reduction in tumour size has been achieved.
As a part of the tool, SusTA tries to offer a transparent assessment, based on a rather simple method using only few data, to provide an operable tool for developing countries' contexts.
The B-18 trial did not demonstrate superiority of neoadjuvant over adjuvant chemotherapy for operable breast cancer, but with equivalent survival and increased BCT, the neoadjuvant approach can safely be used to offer BCT to more women with breast cancer.
To offer condolence?
Since local control rates after SBRT are comparable to those obtained with surgery, it could be argued that primary SBRT might also be offered to operable patients as an alternative to lobectomy.
Bike racks merely encourage cycling to work, and operable windows merely offer the opportunity to use less air-conditioning.
Offer to listen.
Offer to pay more.
Offer to walk away.
If the design is found to be poorly operable, dynamic operability can be enhanced only by appropriate process design modifications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com