Sentence examples for to mfn from inspiring English sources
10.7554/eLife.01958.006 Figure 3. MUL1 physically binds to Mfn, and promotes ubiquitination-mediated Mfn degradation.
MUL1 physically binds to Mfn and promotes its ubiquitin-dependent degradation.
Follow-up investigations revealed the progression to MFN only in a small number of patients.
Biochemically, MUL1 binds to Mfn, and loss of MUL1 results in decreased ubiquitination of Mfn and increased Mfn levels.
This has not prevented people in the field, including us, from concluding that Parkin binds to Mfn.
Expression of wild-type MUL1, but not a ligase-dead version, suppresses PINK1 or parkin mutant phenotypes, and those due to mfn overexpression in Drosophila.
Similar to Mfn-2 (32), P1b was shown to be localized in the outer mitochondrial membrane, where it is anchored via its isoform-specific sequence that serves as a single-anchor domain (10).
As to Mfns, no direct link with Ca2+ regulation has been proposed.
Bill Paxon, a prominent House Republican who used to support MFN, has now switched sides.
They are also a wasting asset, since they are relative to an MFN tariff that will probably decline with further multilateral liberalisation.
(B ) The PINK1/parkin pathway and MUL1 act in parallel to regulate mfn, and maintain mitochondrial function and tissue health.
