Furthermore, the short-term nature and pre-treatment design of the study as well as the lack of direct measurements of time-related changes in tissue PARP activity and 3-nitrotyrosine (an index of peroxynitrite) make the applicability of the results to the clinical scenario problematic.
These and other changes in the treatment landscape make the applicability of results from RTOG 9802 to all patients less clear.
Synthesized nanocomposites with adjustable particle sizes and controllable magnetic properties make the applicability of Co-ferrite even more versatile.
The above aspects make the applicability of our study limited until its results can be verified and compared with the results of future studies on an evening dosing schedule of bimatoprost.
These techniques, however, can currently be used on a wide diversity of species, and the expanding availability of sex-specific antibodies, X- and Y-linked genetic markers, and genome-wide sequences of nonmodel organisms, will make the applicability of the screen expand with time.
Finally, having a relatively fit sample with moderate to good control of their diabetes makes the applicability of the outcomes to individuals who are inactive or have poor glycemic control uncertain.
Study limitations (eg, trial design, analytic methodology, patient selection criteria, and lack of specificity of therapeutic intervention), however, have made the applicability of findings to a general AF patient population difficult.
Moreover, given that at the time of analyses, clustering of some racial/ethnic groups in broader categories was made, the applicability of our results to underrepresented racial/ethnic groups could be limited.
This result makes the applicability of the algorithm clear.
This makes the applicability of this theorem – and hence the defense of market solutions in such cases – problematic.
