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Repeated exposition to benign and tolerated pathogens leads to the production of regulatory T cells, which helps to maintain tolerance.
The mechanisms underlying the failure to maintain tolerance that allow for maturation and activation of autoreactive cells in SLE that are specific for DNA remain incompletely understood.
The fetus is exposed to a unique environment and needs to maintain tolerance both towards non-inherited maternal antigens and self-antigens that arise during its development.
Hence, the authors further speculated that CCR7-expressing immature DCs that ingested apoptotic material may migrate to peripheral lymph nodes, in order to maintain tolerance [26].
Therefore, we speculate that NKT cells are important for the initiation and control of the fetal Th2 environment which is needed to maintain tolerance towards self-antigens as well as non-inherited maternal antigens.
Therefore, we speculate that NKT cells are important for the initiation and control of the cord blood Th2 environment which is needed to maintain tolerance towards self-antigens as well as non-inherited maternal antigens.
Similar(32)
The immune system has evolved a variety of mechanisms to achieve and maintain tolerance both centrally and in the periphery.
NKT cells, which are potent producers of cytokines, foster protective immunity to microbes and tumor cells, but also help maintain tolerance to self.
In contrast, c-FLIPL transgenic (Tg) mice in the C57BL/6 (backgroundound maintain tolerance to nuclear antigens, and are resistant to the development of lupus-like disease.
The intestine is a complex organ that must maintain tolerance to innocuous food antigens and commensal microbiota while being also able to mount inflammatory responses against invading pathogenic microorganisms.
Regulatory T (Treg) cells establish and maintain tolerance to self-antigens and many foreign antigens, such as allergens, by suppressing effector T-cell proliferation and function.
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