In C57Bl/6 mice PrPSc deposition and spongiosis was predominantly found in the cerebellum, pons, entorhinal cortex, medulla and to lower extends in the thalamus.
Here, intensive active caspase-3 staining can be found basically in all areas where spongiform vacuolation is found, and to lower extends also in areas of the brain without obvious neuropathological changes.
In the homozygous ami-ppd-SAUR19 OE line, we observed an increased cell number compared to the WT, but to a lower extend than in the ami-ppd line, and an increased cell area similar to that of SAUR19 OE.
In the present study, significant amounts of the polyamines cadavarine, diethanolamine and to a lower extend spermidine were detectedin response to the development of mycorrhizal structures in the root cortex (Fig. 2, Additional file 3: Figure S2).
As it has been demonstrated that they are phagocytosed by the monocyte/macrophage system and to a lower extend by granulocytes [15], [16], the idea of this study was to use PFCs instead of ironoxide nanoparticles to visualize infection sites by MRI.
Fatty esters follow this same tendency but to a lower extend.
Another approach was the administration of PFCs into the blood stream, where they are phagocytosed by the monocyte/macrophage system and to a lower extend by neutrophils [15], [16].
Amaya lparraguirre reported that although both influenza virus and CpG led to increased expression levels of costimulatory molecules on PDCs, including CD40 and CD86 as well as MHC II, an exception was CD80, which was expressed to the lower extend under the CpG stimuli than the influenza virus stimuli [38].
In addition we could identify amino acids accumulating to a lower extend in arb cells.
A 3.0 kb mRNA was detected in kidney and, to a lower extend, in placenta (Fig. 1).
