Sentence examples for to irp from inspiring English sources

This study revealed that procurement prices of surveyed medicines were reasonable in comparison to IRP.

However, the situation is totally different in erythroid cells, which express a heme synthetic ALAS2 isoform that contains a 5′ IRE and is subject to IRP repression and a specific FPN1b transcript that does not have a 5′ IRE and can therefore evade repression by IRPs when there is cytosolic iron deficiency (65).

Likewise, preliminary observations that DOX-sensitive or DOX-resistant tumor cells exhibit different ratios of aconitase to IRP-1 might anticipate a possibility to target iron trafficking in sensitive cells while not affecting iron homeostasis in the heart.

The absence of any IRP2-dependent alterations in VEGF levels may suggest that the H1299 cells primarily express HIF-1α, that is unresponsive to IRPs.

Time to death in hospital analyses showed a beneficial DrotAA treatment effect but no additional benefit to knowing IRP A or IRP B genotype (Fig. 2).

However, the difference in molecular weight relative to IRP-1 or IRP-2, as well as the negative effect of β-mercaptoethanol on RNA-protein complex formation, suggests the presence of atypical RBPs in this particular mechanism.

Further information could be obtained by subjecting animals with tissue-specific or general deficiency of IRPs to stressful stimuli that have been demonstrated to affect IRP activity.

Taken together, our observations in patients with malignancies affecting the lungs bear resemblance to an IRP, which has been described as a more pronounced form of immunosenescence [ 6].

The RNA hairpin structures specifically bind to human IRPs [ 36] and to proteins present in cytoplasmic extracts from T. vaginalis grown under iron-restricted conditions [ 92].

These data suggest that Mn appears to stabilize the binding of IRP to DMT1 mRNA, thereby increasing the expression of DMT1.

Tom McPhail of Hargreaves Lansdown agrees: 'Standard Life, Axa and the Pru are all looking at it - but the reason they have been slow to jump in is that they have all struggled to square the circle on the pricing.' UK pensioners have been able to buy IRPs for about 18 months from three other US companies - MetLife, Hartford and Lincoln.