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These genes are potentially involved in communication between the blastema and surrounding tissue to instruct the development of missing tissues in injured animals.
Given the substantial resources invested in NRP1-targeted anti-angiogenesis therapies for vascular disease and cancer, the information gleaned from this study will be invaluable in identifying the cellular and molecular mechanisms underlying angiogenesis and ultimately using this information to instruct the development of new therapeutic approaches.
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Here, Tal1 appears to specifically instruct the development of V2b GABAergic neurons from an initially bipotent postmitotic precursor pool (Del Barrio et al., 2007; Peng et al., 2007).
Daussy, C. et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow.
A better understanding of the changing mechanisms that control growth factor release during the different stages of preclinical development could instruct the development of future scaffolds for currently untreatable injuries and diseases.
This understanding in turn can instruct the development of transition-state analogue inhibitors, which have exciting potential as drug candidates.
We outline research and practice gaps and best practice models within and outside Africa that can instruct the development of future interventions.
Real-time feedback may help to instruct the novice in minimising the resultant displacement of the spine whilst concentrating on the development of other variables which maybe important to the successful application of such techniques.
All volunteers have been instructed to assist the development of purely political and democratic programmes through exclusively peaceful means.
Given the ongoing debate about whether neuronal activity instructs the development of neuronal circuits [ 37, 38], we believe it is important to understand the spatiotemporal properties of waves in different recordings.
Notably, IFN-γ induced histone acetylation at the promoter regions of the Tnf and Nos2 loci in the monocyte and macrophage lineage, indicating that IFN-γ-dependent epinstructsregulathen instructs the development of the colitogenic monocyte and macrophage lineage in vivo.
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