Similar to STA-21, but unlike the compounds we identified, no evidence of the ability of S3I-201 to directly bind Stat3 or to inhibit the binding of Stat3 to its pY-peptide ligand was presented leaving open the question of the precise mechanism of action of S3I-201.
We hypothesized that calcimycin-dependent growth inhibition may result from its ability to inhibit the binding of Fli-1 to its target gene DNA.
It has been reported that increased expression of GBGT1 reduces the susceptibility to microbial toxins (e.g., Shiga toxins) because Forssman glycolipids, which do not bind microbial toxins, are thought to inhibit the binding of toxin by replacing toxin-binding glycolipid [28].
The antibiotic mithramycin binds to G-C rich DNA sequences to inhibit the binding of SP1 [ 47].
The pentapeptide NKISK has been reported to inhibit the binding of decorin to fibronectin.
Under the experimental circumstances, MabVV34 was able to inhibit the binding of VVLB4 to Tn.
Ability of this mimic to inhibit the binding of the natural Glc1Man9GlcNAc oligoside to calnexin has been measured.
For competition studies, the IC50 for each drug to inhibit the binding of 125I-SP in each species was determined by plotting the specific bound at each concentration of drug, after which non-linear regression analysis was performed.
To investigate the effects of human follicular fluid cultured with cumulus cells to inhibit the binding of spermatozoa to the zona pellucida of oocytes.
Novel pyrone-derived quorum sensing (QS) ligands to inhibit the binding of OdDHL to the LasR of Pseudomonas aeruginosa were designed, synthesized and evaluated.
RGD-containing peptides are able to inhibit the binding of ligands to certain β3 integrins, such as αIIbβ3 and αvβ3, both of which are involved in neointimal hyperplasia.
