Sentence examples for to inferring the function of from inspiring English sources

The results shown in the present study, together with this previous transporter study, suggest that the validity of gene-to-gene coexpression analysis is not limited to genes involved in protein complex formation or transcriptional regulation, but is also applicable to inferring the function of various types of uncharacterized genes.

Thus, a functionally characterized lncRNA (reference) can be used to infer the function of others that are functionally unknown (target), based on shared structural motifs.

Thus, a functionally characterized lncRNA (here called reference) can be used to infer the function of other lncRNAs that are functionally unknown (here called target), based on shared structural motifs.

The most straightforward approach of computational functional annotation is to infer the function of a gene based on the functions of genes returned by a database search for similar genes.

To elucidate functional divergence among the Gsdma-related genes in mice, and to infer the function of the human and rat orthologs, we examined in vivo function of mouse Gsdma by generating Gsdma knockout mice and transgenic mice that overexpress wild-type Gsdma or Gsdma harboring a point mutation (Alanine339Threonine).

A reliable identification of interfacial residues is vital not only to infer the function of individual proteins and their assembly into biological complexes, but also to elucidate the molecular and physicochemical basis of interactions between proteins.

For instance, protein interaction networks can be used to identify hub proteins having critical biological functions, to predict biological pathways, and to infer the function of a protein according to its interactions with other proteins with known functions [22] [24].

Our ability to detect several significant associations suggests that association mapping in the ancestral population can be used as an initial step to infer the function of some selection-candidate genes.

In fact, FLJ10540 does not share similar expression patterns with VEGF-B, at least not in our lung cancer microarray, supporting the idea that synexpression patterns could be used to infer the function of unknown genes [27].

Gene-to-gene coexpression analysis is a powerful approach to infer the function of uncharacterized genes.

Several lines of evidence can be used to infer the function of an uncharacterized protein.