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Tolerance is particularly troublesome as this leads to increased dosing and more side effects.
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In this case, the reduced angiogenesis was shown to be due to increased doses of Adamts1, Erg, Jam2 and Pttg1ip.
For example, tumors that acquired the same mutation that conferred imatinib resistance responded differently to increased doses of imatinib [ 110].
Therefore, doctors have great flexibility to increase dosing — and profits.
One way to lower homocysteine is to increase doses of the B vitamins: folic acid and vitamins B6 and B12.
We used quantitative coronary angiography to delineate the vasomotor response to increasing doses of acetylcholine given intracoronary.
An international team of researchers assessed the responses of 48 patients to increasing doses of nivolumab, and then treated another 214 people with a fixed dose of the drug.
Responses to increasing dose of enzyme were generally linear or curvilinear, and the optimum dose rate differed amongst the products evaluated.
Most divergences reflected a failure to increase dose when indicated.
Fig. 3 a Proportion of A. ferus adults sterilised after exposure to increasing doses of radiation.
b Proportion of A. ferus eggs sterilised after exposure to increasing doses of radiation.
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