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These data demonstrate that CTG tracts, greater than 250 repeats, may be necessary to increase steady state Cug-bp1 levels, in adult mouse tissues.
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The preincubation with AgNP leads to increase steady-state luminescence as shown in Fig. 3.
NF-kappaB was important to increase steady-state MDM2 protein levels rather than in affecting p53-dependent transcription, suggesting a unique mechanism by which LCLs survive in the presence of a primed p53 pathway.
The bipyridyl herbicide paraquat (PQ2+) was used to increase steady-state levels of ROS in primary midbrain cultures.
We have tested this possibility in an experimental mouse model, in which we used rIL-11 to increase steady-state levels of VWF over a prolonged period of time.
This timing supports our model that the primary effect of SXR activation in these breast cancer cells is to increase steady-state levels of iNOS mRNA which then leads to increased production of NO.
Thus, although we cannot completely rule out the possibility that the presence of WT SOD1 in some manner stabilizes the mutant protein to increase steady-state levels in spinal cord, we think that the weight of evidence favors another explanation.
If normal dimeric interactions between WT and mutant SOD1 were by some manner responsible for stabilizing the mutant protein to increase steady-state levels, then one might expect that these poorly dimerizing mutants would be less affected by co-expression of WT SOD1.
In addition to increased steady state Mcl-1 and Bcl-xL mRNA levels, MCL-1 protein was also more stable in ABT199-R cells.
However, looking at the coefficient of variation (CV) both nuclear phospho-p38 and cytosolic phospho-Hsp27 show a decrease of variation with increasing stimulation due to increasing steady state particle numbers.
It has been shown by Bate et al. [ 93] that a mutation of talin that blocks cleavage by calpain 2 at a newly found binding site indeed leads to increased steady state levels of talin1.
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