This controlled for potential effects of repeated sucrose stimulation that could lead to increased sensitization or habituation.
Taken together, the IFNAR1 expression data from the colitic and healthy mice, as well as the effect of IFNAR1 loss or downregulation in IFNAR1−/− mice or in vitro cultures respectively, suggest that the loss of IFNAR1 expression may correlate with a decreased ability to generate Tregs, which in the course of DSS colitis may ultimately lead to increased sensitization.
ROS production may be one of the mechanisms contributing to increased sensitization of Kupffer cells to LPS in the alcoholic liver (Thakur et al. 2006).
Stress and the subsequent stimulation of inflammation (systemic and local) lead to increased sensitization of pain and further defects of stress response systems (vicious cycle of stress, pain, and inflammation).
As previously shown, increased expression of RKIP in breast and prostate cancer cells leads to increased sensitization to chemotherapeutic agent as measured by CPT induced apoptosis [ 11], a similar mechanism may explain the role of RKIP in the resistance to chemotherapeutic agents in CRC patients.
Exposure to airborne PM exacerbates the physiologic responses leading to asthma, such as airway inflammation, and may also increase sensitization to allergens resulting in atopy, a risk factor associated with asthma (Dockery et al. 1993; Pope et al. 1995).
For example, female mice exposed to environmental tobacco smoke, which is known to increase allergic sensitization, and then sensitized with OVA demonstrated greater OVA specific IgG1 and IgE in their serum compared to males [ 50, 51].
On the other hand, excessive band-selective filtering may lead to paranoia; indeed, increased sensitization and reduced habituation are trait markers of patients with schizophrenia [ 179].
It has the potential to increase tumor sensitization to radiation and chemotherapy while reducing some of the most common side effects of these conventional therapies [ 17].
