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The findings, published in the April issue of Nature Neuroscience, might lead to new drugs to improve memory function in amnesia and neurodegenerative diseases.
I head a diverse team of researchers that study these neurobiological mechanisms in rats, mice, and humans, and lead a series of studies to test treatments in animals as well as a clinical trial in humans designed to improve memory function in older adults who suffer from memory problems such as patients with mild cognitive impairment who are at risk for Alzheimer's disease.
The work of Govindarajan et al is of note since the HDAC inhibitor sodiumbutyrate was only applied after the onset of severe AD pathology and was still able to improve memory function.
Also, we aim to provide an overview of the concept and current findings regarding the use of intranasal insulin to improve memory function in healthy and cognitively impaired humans.
Trh mimetics have been shown to improve memory function (Olson et al., 1995) and interestingly pro-Trh mRNA levels are increased in the anterior hippocampus in rats trained in the Morris water maze paradigm (Aguilar-Valles et al., 2007).
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5 In a randomized placebo-controlled trial examining the effect of memory training, findings suggested that a six-week training on categorization and visualization techniques failed to improve memory functioning in a group of probable AD patients.
Some studies suggest that only 5-min acupuncture stimulation can improve memory function in animal models and it appears to have a therapeutic effect on several pathological disorders.
Altogether, these results show that positive life events such as exposure to a variety of new (and changing) stimuli throughout life may improve memory function by increasing neurogenesis during the course of aging.
Thus, it is interesting to note that a number of studies found that HDAC inhibitors also improve memory function in aged rodents (Fontán-Lozano et al, 2008; Peleg et al, 2010; Reolon et al, 2011).
Since higher levels of hippocampal neurogenesis are typically associated with improved cognitive function11,12, in what way might neurogenesis-mediated clearance improve memory function?
Studies have shown that administering specific nutrients may improve memory function, possibly by increasing synapse formation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com