Not all practitioners are seasoned epidemiologists Even with committee guidelines, research editorials and journal reputations, young clinicians must navigate through this data and reflect on its quality and relevance before making a decision to implement findings in a real-time clinical setting.
Many were well-placed to implement findings or advocate for consumers.
Success also includes paying attention to scale-up and sustainability issues from the very beginning; without the vision of how the findings can be used, the stakeholder support needed not only to implement findings but also to assist in operationalizing the research itself, may well be undermined.
If translating research into positive gains in health status is accepted as a criterion for excellence, GHR needs to develop, apply and evaluate means to demonstrate the value of new knowledge and to discover ways to implement findings in a timely and effective manner.
There is a shortage, particularly in lower-income countries, not only in terms of technical expertise to undertake economic evaluations in the first place, but also in terms of health service management capacity or political willingness to translate and implement findings into everyday health care practice.
However, it is important to note that although it is beyond the scope of this paper, the individual country economic development status (amongst other individual country characteristics) is likely to influence research productivity as some countries have far more resources and increased capacity to both conduct research and implement findings when compared to others [ 3, 15, 16].
Overall, our modeling approach provides means to suggest new experiments and implement findings at multiple scales in order to understand how network topologies and subcellular heterogeneities can influence signaling events at individual organelle level, and hence, determine the emergence of heterogeneity in cellular decisions due the actions of the collective intra-cellular population.
So third, Born This Way Foundation, with input from the diverse teens who make up its Youth Advisory Board, has begun to implement these findings into real resources that young people find accessible and effective.
Conducting a trial in a single centre removes between-centre heterogeneity, but when such trials (for example, those of early goal-directed therapy for severe sepsis [ 2] and of tight glycaemic control in critically ill patients [ 3]) find treatment effects, physicians can be reluctant to implement the findings if they suspect they were unique to the study institution [ 4, 5].
Below, we highlight six of the key findings in the V&C Executive Summary, note some of the recent documents that resonate with those findings, and give a few examples of actions under way to implement these findings.
