As we did not observe dendritic targeting of reporter mRNA by any of the ID elements in transgenic mice, we reasoned that, possibly, the 5' domain alone is insufficient to impart targeting competence to the non-dendritic EGFP mRNA in vivo.
The properties of M-13 bacteriophage can be systemically modified to impart target-specific selectivity and sensitivity using the phage display technique.
Polymer bioreducibility was used to reduce potential cytotoxicity and to impart cytoplasmic targeting of siRNA release.
Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (poly-2-vinylpyridine) is considered here in order to impart possible active targeting of the tumor cells.
Here, both genetic and chemical strategies were used to impart cell-specific targeting to the Hsp cage from Methanococcus jannaschii.
First, we present approaches to engineer stimuli-responsive characteristics into multilayers to facilitate sensing, drug loading, and drug release; second, we cover functionalization of the surface to impart stealth-like and targeting properties; and finally, we discuss approaches for loading different therapeutics into the interior of the capsule.
T is embedded in a (channel-regulatory) acid-rich region [ 26] close to the C-terminus, whereas S lies within a site that interacts in vitro with F to impart regulation towards CK2 targeting and or function [ 20, 21].
Herein, we examined the application of cyclic compounds containing the Arg-Gly-Asp (RGD) sequence as to impart tumor-specific ligands for targeting Bchl-Ds/SA to necrotic tumor domains.
The most natural and universal way to impart the affinity toward the target to a nonspecific drug is the binding of this drug with another molecule (targeting moiety) capable of specific recognition and binding at the target site.
Resistance mutations may be expected to impart a fitness cost because they target important biological functions in the cell (Table 1).
This paper presents basic ideas behind a directed energy planetary defense system that utilizes laser ablation of an asteroid to impart a deflecting force on the target.
