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As for the influence of HT source, tetranucleotide-based methods (oli.chi2, oli.KL and signature) and the dinucleotide-based method (dint5) are less sensitive to host variation compared to GC based methods (GCtotal and GC1-GC3) or codon usage based methods.
However, these findings have not been demonstrated in vivo or in a species demonstrating Bd susceptibility in nature, and further studies are needed to assess whether this lymphocyte-killing mechanism contributes to host variation in susceptibility.
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The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial.
This is the first study to firmly establish that certain types of gut microbes are heritable — that their variation across a population is in part due to host genotype variation, not just environmental influences.
We used this host variation to test how host genetics change pathogen growth dynamics.
This argument is supported by recent studies (Y ates et al. 2006; N ath et al. 2008), which found that predictions for epidemic characteristics are sensitive to the source of host variation.
These findings suggest that Spiroplasma has other effects on hosts that allow it to persist, and that environmental or host variation affects transmission or persistence leading to differences among populations in infection frequencies.
However, in contrast to what is observed for host variation in susceptibility, variation in host infectivity (TD or κD) can substantially affect the risk of disease establishment in all environments.
The maintenance of host variation in tolerance to pathogens and parasites.
Norrby-Teglund, A. et al. Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infection.
This differential impact of bacterial effectors on plant gene expression due to the genetic context highlights the importance of host variation in the determination of parasite fitness traits.
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CEO of Professional Science Editing for Scientists @ prosciediting.com