Bispecific activity of a single linear sequence oligo has already been shown to have efficacy.
Eperisone also improved paraspinal blood flow and was found to have efficacy similar to tizanidine in chronic LBP patients.
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain.
Previously, we reported that a symmetric mono-carbonyl analog of curcumin, (C66), exhibits enhanced stability and was found to have efficacy and be involved in potential cytokines inhibition.
Monotherapy with paclitaxel appears to have efficacy similar to inhibitors of epidermal growth factor receptor tyrosine kinase (gefitinib and erlotinib) (TKI-EGFR).
In addition, various other antioxidant agents that have been shown to have efficacy in preclinical TBI models are briefly presented, such as the LP inhibitors U83836E, resveratrol, curcumin, OPC-14177, and lipoic acid; the iron chelator deferoxamine and the nitroxide-containing antioxidants, such as α-phenyl-tert-butyl nitrone and tempol.
"Calamus is a very important component of Ayurvedic medicine and has been shown to have efficacy," according to Musselman.
"Psilocybin [best known as the active ingredient in "magic mushrooms"] is now being shown to have efficacy in treating depression, anxiety, and some addictions.
The combination amodiaquine (AQ) plus SP has been shown in some African countries to have efficacy similar to ACTs [5].
In keeping with a role for CCR4 on Th2 cells, anti-CCL17 and anti-CCL22 antibodies have both been observed to have efficacy in murine asthma models.
In the early 1980's Mendelsohn and colleagues developed the monoclonal antibody C225 (now called cetuximab) and showed it to have efficacy in inhibiting cancer cell growth both in vitro and in vivo [10].
