The closed questions detailed in the schedule were not directed towards the participants, but simply used as a guide by the interviewer to the topics to be covered and to identify further relevant areas of interest.
Being able to recognize and classify facial dysmorphism can lead physicians to consider alternative diagnoses or to request further relevant investigations, and this could be aided by the increasing use of 3D stereophotogrammetry in clinical settings (Heike et al., 2010).
Moreover, family doctors, other physicians and collaborative relatives were involved in the attempt to collect further relevant information, particularly with regard to the most distant branches of the family or to individuals living in other regions.
To identify extra data on HNSCC, solid tumor studies were firstly considered to verify whether it was possible to extrapolate further relevant information in HNSCC cases.
They knew it is wise to check first what the patient already knows, in order to give further relevant information, taking into account the patient's ability to assimilate the messages.
Since we used additional snowballing technique to identify further relevant publications, we believe the search strategy employed to be sufficiently specific.
In addition to this search procedure, we used the reference lists of the identified publications to find further relevant articles.
