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However, in humans, who have especially high cerebellar activity coupled with long lifetimes, it is likely insufficient to rescue neural viability and the most sensitive cells eventually cease to function sufficiently and/or die, resulting in AOA1 pathology.
We attribute the difference to the monoallelic nature of our reporter and its apparent ability to function sufficiently with endogenous Fast-1 (Sirard et al., 2000) or with Fast-2 (Nagarajan et al., 1999), in comparison with transfected or injected constructs that involve many DNA copies per cell.
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Competition for limited substrates or associated molecules may interrupt normal PTEN function sufficiently to lead to increased proliferation and diminished apoptosis.
The quantity, morphology, and motility of sperm recovered from the epididymus at both ages were also normal, suggesting that despite reduced testosterone, the male reproductive organs develop and function sufficiently to produce a normal number and quality of gametes.
It is possible that an impaired defence mechanism, perhaps in the form of locally reduced CRP response in the tumour, could result in excess cellular fragments and prolonged inflammation in the tumour because CRP cannot function sufficiently to remove all cellular debris and/or apoptotic cells in the prostatic lesions.
The typical transparent skin phenotype in knock-out silkworms was stable and inheritable, suggesting that N20NGG sgRNAs function sufficiently in vivo.
In contrast, these endogenous recovery mechanisms do not function sufficiently in patients with chronic ischemic symptoms and co-morbidities (Fig. 2C).
Her body rejected the new organ after several weeks — anti-rejection drugs had not been developed — but the transplant provided time for her other kidney to begin functioning sufficiently, Dr. West later said in interviews.
However, the two 'A's can be totally different in, for example, structure, as long as they are functioning sufficiently similar to allow the cycle to close.
Let's hope our democracy is functioning sufficiently well for these ideas to get the consideration they deserve.
The evaluation showed that the technical infrastructure that was used for collecting syndromic surveillance data in a rural part of central India functioned sufficiently well.
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CEO of Professional Science Editing for Scientists @ prosciediting.com