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For example, Hif1 has been shown to physically interact in a stoichiometric manner with Hat1 and Hat2 in S. cerevisiae and is involved with acetylation of newly synthesized histone H4, whereas Sim3 which is a fission yeast NASP homolog appears to function specifically in the deposition of centromere-specific histone H3 variant CENP-A [ 14, 20].
The syrinx depends on the air sac system in birds to function; specifically, it requires the presence of a clavicular air sac near the wishbone or collar bone.
Because comprehensive biochemical and expression data have been obtained for relatively few OBPs demonstrated to function specifically in chemosensory signal transduction [21], [55], [60], generalizations regarding their forms of post-translational modification and sites of expression should be viewed cautiously.
At least some of the genes in cluster c encode proteins that are thought to function specifically in conjugation such as CnjB (Noto, Bednenko and Gorovsky, unpublished observations) and Lia 6 [51], indicating either that these genes have multiple functions or, more likely, that preparation for the expression of some proteins required in large amounts during conjugation begins during starvation.
FoxA appears to function specifically in a subset of stem cells to drive pharynx regeneration in adult animals.
Therefore, the Erv41-Erv46 complex appears to function specifically as an ER exit adaptor protein for Ktr4 in yeast.
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Altered hair form or mammary function can not readily be linked to functions specifically required by humans for adaptation to a dry, cold environment; conditions that increase evaporation from exposed surfaces, leading to drying of the eyes, nose, mouth, throat and skin, and to cooling of the skin [51].
It is suggested that EA expression on tumour cells is related to a cell membrane function controlling mitosis rather than to a function specifically related to the neoplastic status.
One was related to the mobilization of energetic resources, in particular facial muscles [ 19], and another was related to neurotransmitter function, specifically the 5-HT descendinhibitorytory pathway [ 20].
The ability to modulate function specifically and rapidly makes small molecules especially useful tools for studying processes like development in which the timing of protein function is critical.
Eighteen of the 93 genes, which resulted in protracted fermentation when deleted, were annotated to vacuole function, specifically the vacuolar H+ ATPase complex.
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