Sentence examples for to fully activated from inspiring English sources
However, this raises the question of why its expression does not lead to fully activated fibroblasts early in disease progression.
73 As for CTLs, time series of lymphocytes selectively activated to cytotoxicity (that lacks a mature immunological synapse) show that these cells have signaling patterns with lower average calcium mobilization compared to fully activated CTLs.
A similar method was used to assess the number of microglia identified with the immunostaining for Iba1, a calcium-dependent molecule that is a widely recognized marker of macrophages and microglia and is known to be expressed in ramified, quiescent to fully activated microglia [ 46].
Upon recruitment to the cell membrane AKT is phosphorylated at two critical residues, T308 in the activation T loop, and S473 in the hydrophobic domain, to fully activate its kinase activity.
The addition of 6 mM exogenous Ca2+ was sufficient to fully activate the transamidating activity (approximately 8 fold over vector control) for all of TG2 constructs that were catalytically active: wild type, R580A-TG2 and Y516F-TG2.
However, this essential recruitment step is not sufficient to fully activate the formin activity; this is in contrast to Rho-mediated recruitment of Dia1 to the membrane where this appears sufficient to also release DID-DAD interactions, (Fig. 1A).
RAC is activated in proximity to p110β and binds to the RBD to fully activate p110β lipid kinase activity (schematic in Figure 6F).
Activated SYK phosphorylates BLNK, thereby leading to the formation of BCR signalosome to fully activate the downstream PI3K, mitogen-activated protein kinase (MAPK), and NF- κB pathways [ 26].
According to the currently accepted model of T cell activation, two signals are required to fully activate resting naïve T lymphocytes.
15, 18 QFM weakness related to OA may stem from voluntary activation failure (ie, an inability to fully activate the QFM) and/or muscle atrophy.
We demonstrate that Stim1 Orai1 clustering at ER PM junctions is insufficient to fully activate SOCE unless followed by a α-SNAP dependent active molecular re-arrangement within CRAC channel clusters.
