Upon recruitment to the cell membrane AKT is phosphorylated at two critical residues, T308 in the activation T loop, and S473 in the hydrophobic domain, to fully activate its kinase activity.
The addition of 6 mM exogenous Ca2+ was sufficient to fully activate the transamidating activity (approximately 8 fold over vector control) for all of TG2 constructs that were catalytically active: wild type, R580A-TG2 and Y516F-TG2.
RAC is activated in proximity to p110β and binds to the RBD to fully activate p110β lipid kinase activity (schematic in Figure 6F).
Activated SYK phosphorylates BLNK, thereby leading to the formation of BCR signalosome to fully activate the downstream PI3K, mitogen-activated protein kinase (MAPK), and NF- κB pathways [ 26].
According to the currently accepted model of T cell activation, two signals are required to fully activate resting naïve T lymphocytes.
15, 18 QFM weakness related to OA may stem from voluntary activation failure (ie, an inability to fully activate the QFM) and/or muscle atrophy.
We demonstrate that Stim1 Orai1 clustering at ER PM junctions is insufficient to fully activate SOCE unless followed by a α-SNAP dependent active molecular re-arrangement within CRAC channel clusters.
However, κB and GATA factors alone were not sufficient for MsMoricin gene activation, suggesting that other co-regulators may be required to fully activate AMP genes.
Robert Bonfante said first had to be sold to the Board of Education and the Town Council and then took three or four years to fully activate.
It also takes about 40 ms to fully activate the small cell.
Aramid fiber requires much longer embedment length to fully activate its bond with asphalt than the polyester fiber does.
