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Figure 9 summarizes the transcriptomic and metabolomic data with regard to flavonoid backbone biosynthesis.
Therefore, the specific contribution of the expressed transcript to flavonoid backbone biosynthesis cannot be deduced from the transcript data.
With regard to secondary metabolism, we observed a significant enrichment of transcripts related to flavonoid backbone biosynthesis in this group (p < 0.05; Figure 2).
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Compared to other flavonoids, maysin has a unique structure in that mannose is bound to the flavonoid backbone.
J. E. Vargas et al. used a network flow approach to predict protein targets and flavonoid backbones to treat respiratory syncytial virus (RSV) infection.
Ratios (log2 fold changes) of transcript expression values and mass intensities were mapped to the KEGG pathways of terpenoid and flavonoid backbone biosynthesis.
Overall, these data indicate that after flavanone consumption, the major circulating metabolites are phenolic breakdown products derived from the flavonoid backbone.
Additionally, there was an increase in positively charged areas with higher activity colored in blue in the vicinity of the hydroxyl group in the 4-hydroxyphenyl moiety and the hydroxyl group in the 3′-position of the C-ring of the flavonoid backbone.
The LC-MS/MS analysis showed that about 20% was chlorogenic acid and more than 70% of the partially purified CGE extract was maysin and its derivatives, which were the major active compounds, contains a mannose bound flavonoid backbone that may be easily absorbed in the body.
In the present analysis, we observed a significant enrichment of transcripts related to the biosynthesis of flavonoid backbones in the TCO < SCO-group.
This observed reduction may be attributable to flavonoids contained in cocoa and dark chocolate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com