Dictionary
to externalization
noun
A physical thing that typifies an abstract thing; an embodiment or personalization
Exact(11)
An overview of the empirical findings on externalization is provided and the factors assumed to be conducive to externalization are outlined.
This indicated that de novo synthesized tTG is targeted to the PNRC prior to externalization.
The initial recruitment of cytoplasmic tTG to the endosomal membranes depends on phosphoinositide binding, and membrane-bound tTG is delivered inside the perinuclear endosomes prior to externalization.
Therefore, cytoplasmic tTG binds to and is delivered inside the Rab11-containing PNRC shortly after onset of its biosynthesis but prior to externalization.
The de novo synthesized cytoplasmic tTG does not follow the classical ER/Golgi-dependent secretion pathway, but is targeted to perinuclear recycling endosomes, and is delivered inside these vesicles prior to externalization.
Thus, to define intracellular localization of tTG prior to externalization, we used pre-extraction of majority of cytoplasmic tTG in NIH3T3-tTG fibroblasts shortly after onset of its synthesis and before the protein reached the surface (Fig. 3B).
Similar(49)
Efficiency compared with quality of the knowledge acquired can provide a good mechanism to select the most suitable technique to knowledge externalization for each situation.
In addition to PS externalization, apoptotic cells have further modifications to their membrane constituents.
The striking difference in activity of Bcl2-cb5 and BclX-cb5 was also evident when TNFα induced apoptosis was assessed qualitatively by staining cells with Hoescht dye (to visualize chromatin condensation) and Annexin V (to visualize externalization of phosphatidylserine at the plasma membrane).
The two syndromic groups showed broadly similar profiles of auditory spatial deficits relative to healthy older controls, with sparing of discriminability of cues to sound externalization but impaired discrimination of sound motion and static position in external space.
The results of the present study suggest that lead exposure can lead to the externalization of PS and generation of MVs in erythrocytes, which appears to be associated with increased erythrophagocytosis by renal tubular cells.
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